Simply aging.

Aging is framed as a default outcome of living in which imperfect biological processes drive progressive accumulation of deleterious change, eroding functional reserve over time.

• Why it matters: The field lacks a single mechanistic narrative, so this framework aims to make aging biology simpler and more accessible while unifying diverse aging phenomena.
• What they did: It proposes the “deleteriome” concept to connect molecular damage, regulatory drift, maladaptive remodeling, and system-level failure, while emphasizing evolution’s role in maintenance trade-offs.
• The result: It links first principles to biomarkers and interventions, noting biological age is heterogeneous, modifiable by environment, and in some contexts partially reversible or resettable, though aging itself is irreversible.

AI summary of the abstract · may contain errors · not medical advice · read the paper.