In vitro study of gut microbiota-mediated response to Salmonella Typhimurium with a focus on dynamics and immune modulation.

Human gut microbiota in an in vitro fecal fermentation model shifts communities by increasing SCFA-producing taxa and decreasing Escherichia-Shigella during Salmonella enterica serovar Typhimurium exposure.

• Why it matters: Salmonella enterica serovar Typhimurium disrupts gut microbial balance and triggers intestinal inflammation, but the microbiota-linked dynamics and immune modulation mechanisms remain unclear.
• What they did: In vitro fecal fermentation and Caco-2 co-culture assays assessed microbiota composition and measured host inflammatory markers (IL-1β, IL-6, and c-Jun) alongside bacterial growth, cytotoxicity, and epithelial viability across doses.
• The result: Gut microbiota inhibited Salmonella enterica Typhimurium growth and host interactions while attenuating cytotoxicity and inflammatory responses in a dose-dependent manner, and improved epithelial cell viability, supporting microbiota-based infection control strategies.

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