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Disrupting the semantic network shifts activity to domain-general brain regions.
Nature Communications · · Journal Article · Open access
Schuler, Bruera + 1 more
Abstract ↗AI summary
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High-intensity TMS over the left posterior middle temporal gyrus in 25 healthy participants increases activity in semantic control and lexical retrieval areas plus remote domain-general regions during lexico-semantic decisions.
- Why it matters: Semantic understanding depends on flexible coupling between lexico-semantic systems and control networks, especially when interference disrupts processing.
- What they did: Using TMS interleaved with fMRI, the study perturbed the left posterior middle temporal gyrus during lexico-semantic decisions and measured local and remote BOLD changes.
- The result: Local stimulation-site upregulation correlated with slower reaction times, while stronger domain-general frontal upregulation was linked to less disrupted semantic performance, indicating rapid adaptive recruitment.
The findingWhy it mattersWhat they didThe result
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