DoriC 14.0: an updated database of prokaryotic replication origins with significantly expanded plasmid oriV annotations.

DoriC 14.0 expands prokaryotic replication-origin annotations to 530,178 computational origin records, including 96,118 plasmid records across bacteria and archaea.

• Why it matters: Replication origins are critical for chromosome duplication and plasmid maintenance, yet identifying them reliably is difficult across replicon types and phylogenetic lineages.
• What they did: The update restructures DoriC by combining literature evidence with computational predictions, using OriV-Finder with RNA II-based refinement for bacterial plasmids and a customized archaeal pipeline using replication proteins and origin recognition box motifs.
• The result: The release adds comparative sequence support, related-origin links, RIP similarity networks, plasmid-level recurrence analyses, RIP profiles, and RNA II variation, enabling traceable, versioned browsing and downloads.

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