ECOD in 2027: a modernized interface and an updated classification of protein domains.

ECOD has been rebuilt to classify 2.9M protein domains, including ~1.37M from the Protein Data Bank and 1.51M from AlphaFold predicted models.

• Why it matters: The ECOD web resource needed modernization to improve how users search and access evolutionary domain relationships across both experimental and predicted structures.
• What they did: The team reconstructed ECOD search around sequence, structure, and keyword, using Foldseek against a ~457k representative domain database, with results shown in a Mol* viewer and a new API.
• The result: The updated pipeline and synchronized family groups (Pfam v38.2), reorganized distributables, ligand contact recording with DrugDomain cross-references, and a stable-identifier registry for gene-called proteins enable regular updates and programmatic access.

AI summary of the abstract · may contain errors · not medical advice · read the paper.