Nucleic Acids ResJClub
gutDBase: a comprehensive database for uncovering heterogeneous molecular characteristics of 15 gut-related diseases.
Nucleic Acids Research · · Journal Article
He, Guan + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
gutDBase integrates transcriptomic and microbial data for 15 gut-related diseases, curating 175 bulk and single-cell datasets from 161 publications into one searchable resource.
- Why it matters: Existing large-scale datasets are scattered across studies, limiting systematic analysis and cross-disease comparisons of heterogeneous molecular, cellular, and microbial features.
- What they did: The database compiles curated transcriptomic and microbial measurements and offers an interactive interface with visualization of expression patterns and microbial compositions across diseases.
- The result: gutDBase is designed to support investigations of disease mechanisms, facilitate therapeutic target discovery, and advance translational research for gut-related diseases.
The findingWhy it mattersWhat they didThe result
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