Enabling autonomous remodeling in bone organoids.

Bone organoids grown in liquefied microcapsules support osteoblast, osteocyte, and osteoclast differentiation and enable both matrix deposition and resorption without exogenous inducers.

• Why it matters: Recreating bone remodeling in bone organoids is difficult, limiting studies of how different bone cell types coordinate during matrix formation and breakdown.
• What they did: Pinho et al. built bone organoids inside liquefied microcapsules and assessed whether osteoblast, osteocyte, and osteoclast differentiation occurred without adding external differentiation inducers.
• The result: The system supports matrix deposition and resorption, enabling investigation of cellular interactions that underlie bone remodeling within this organoid model.

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