Integrating blood vessel organoids makes stem cell-derived islets more competent.

Integrating pancreatic islet organoids with blood vessel organoids enhances β cell maturation and resilience, and reverses diabetes in mice.

• Why it matters: Diabetes remains difficult to treat, and islet-vascular interactions are hard to model in vitro without losing key maturation and functional cues.
• What they did: Wang et al. developed an all-stem-cell approach that vascularizes islet organoids by integrating them with blood vessel organoids, then assessed β cell maturation and resilience and tested diabetes reversal in mice.
• The result: The engineered system improves β cell competence and enables a controllable in vitro platform for islet-vascular biology, supporting development of islet transplantation therapies.

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