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A bivalent chromatin reader-WOX5 module maintains root stem cell niche in Arabidopsis.
Cell Reports · · Journal Article
Zhang, Qian + 1 more
Abstract ↗AI summary
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EBS, a bivalent chromatin reader in Arabidopsis thaliana, is essential for root stem cell niche maintenance, and ebs-1 causes QC activation and CSC differentiation.
- Why it matters: Root stem cell niche maintenance depends on controlling QC and CSC activity, but how chromatin regulators connect to key transcription factors is unclear.
- What they did: The study identifies EBS as required for stem cell maintenance, tests domain requirements (BAH, PHD, and a C-terminal SUMO-interacting motif), and shows EBS physically interacts with WOX5.
- The result: EBS promotes WOX5 transcription by enriching at the WOX5 promoter, wox5-1 is epistatic to ebs-1, and WOX5 overexpression rescues ebs-1 defects.
The findingWhy it mattersWhat they didThe result
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