Intravenous Thrombolysis for Acute Ischemic Stroke - New Directions.

Over the past 5 years, intravenous thrombolysis (IVT) for acute ischemic stroke has shifted substantially, including greater integration with thrombectomy and increased tenecteplase use.

• Why it matters: The field has faced a key challenge in combining IVT with endovascular thrombectomy, which improves outcomes for stroke from large cerebral vessel occlusion.
• What they did: This review summarizes vascular targets for IVT and thrombectomy, trends toward tenecteplase rather than alteplase, expanded IVT indications, and adjunct drugs and dosing approaches that may improve IVT success.
• The result: The synthesis highlights evolving strategies that could augment IVT effectiveness, particularly as clinicians broaden who receives IVT and how it is paired with thrombectomy.

AI summary of the abstract · may contain errors · not medical advice · read the paper.