Shapley fields reveal mosaic chemotopic organization in the mouse Olfactory bulb across diverse chemical feature sets.

Shapley fields from widefield epifluorescence in the mouse dorsal olfactory bulb reveal weak chemotopic organization across glomeruli, consistent across PubChem and Graph Neural Network feature sets.

• Why it matters: A natural coordinate system for olfactory stimulus space is missing, making it hard to define receptive-field-like tuning and to determine whether olfactory bulb tuning is spatially organized.
• What they did: The study introduced interpretable Shapley fields that map chemical feature importance for glomerular tuning, then measured dorsal OB responses across a wide chemical space using widefield epifluorescence.
• The result: Chemotopy involved at least three chemical feature dimensions and principal components aligned with commonly accepted chemical classification groups, implying these groups can be identified from mouse olfactory responses.

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