RtmR is a membrane-embedded RRM family RNA-binding protein.

RtmR (VF_2432) is a membrane-embedded RRM-family RNA-binding protein in Vibrio fischeri that inhibits SYP biofilm formation.

• Why it matters: Biofilm development in Vibrio fischeri is regulated by many factors, but negative regulators and how RNA-binding proteins control symbiosis polysaccharide biofilms remain unclear.
• What they did: Using a genetic screen for negative regulators of biofilm formation, the authors mapped RtmR to the membrane, tested RRM motif requirements (RNP1/RNP2), and used iiCLIP-seq to identify RNA ligands, including rscS.
• The result: RtmR’s biofilm inhibition depends on RscS activity and is linked to reduced RscS levels, supporting a membrane-bound RNA-binding regulatory pathway.

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