The Tartary Buckwheat FtMYB15 Coordinates Cadmium Uptake and Detoxification by Regulating FtZIP3 and FtGSTU19 Expression.

FtMYB15 directly binds MBS elements in the FtZIP3 and FtGSTU19 promoters, promoting Cd2+ influx and accumulation while enhancing detoxification in Tartary buckwheat hairy roots.

• Why it matters: Cd contamination threatens food safety, and the key transcriptional links between Cd uptake and detoxification in Tartary buckwheat remain unclear.
• What they did: Using transgenic Tartary buckwheat hairy roots plus Y1H and EMSA, the study tested FtMYB15, FtZIP3, and FtGSTU19 regulation and measured Cd2+ influx, Cd accumulation, and oxidative stress before and after Cd exposure.
• The result: FtZIP3 overexpression increased Cd2+ influx and Cd accumulation, while FtGSTU19 overexpression improved Cd detoxification and oxidative stress relief; heterologous FtGSTU19 expression increased Cd tolerance in Arabidopsis.

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