Spatial coordination in the codevelopment of the human urogenital system during organogenesis.

Mesonephros- and adrenal primordium-derived signals in human embryos (Carnegie stages 15–23) promote gonadal specification and enable efficient in vitro generation of early gonadal lineage–like cells.

• Why it matters: The urogenital system shares an embryonic origin, but the spatiotemporal mechanisms coordinating its multiorgan development are not well defined.
• What they did: Using high-resolution spatial transcriptomics plus single-cell multiomics, the study profiled human embryos across Carnegie stages 15–23 to map codevelopmental dynamics and lineage-linked signals.
• The result: It identifies a possible mesonephric origin of gonadal supporting cells via rete testis or ovarii, and defines three transcriptionally distinct steroidogenic lineages linked to cholesterol sourcing, cortisol synthesis, and sex hormone production.

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