Whole-body single-cell atlas of an adult vertebrate, Danionella cerebrum.

A region-stratified single-cell RNA-seq atlas across the adult teleost Danionella cerebrum maps spatially distinct neural cell types using spatial transcriptomics.

• Why it matters: Whole-vertebrate cell type composition and organization are hard to resolve at single-cell scale, and a complete adult atlas can enable evolutionary and neuroscience questions.
• What they did: The study profiled adult Danionella cerebrum body regions with miniaturized, transparent whole-animal single-cell RNA sequencing, then used spatial transcriptomics to assign cell types by regional gene expression signatures.
• The result: The atlas delineated spatial neural cell types, identified adult molecular positional memory and paedomorphic features, and showed conserved body-region and appendage programs in connective tissue.

AI summary of the abstract · may contain errors · not medical advice · read the paper.