CSE1L enrichment in pediatric and young adult acute myeloid leukemia reveals a ribosomal export dependency.

CSE1L is the highest expressed exportin in pediatric/AYA acute myeloid leukemia and its depletion reduces leukemic growth while sparing normal hematopoietic stem cells.

• Why it matters: Nucleocytoplasmic transport is enriched in younger AML, but its functional dependencies and mechanisms were not well defined.
• What they did: The study analyzes AML cells from patients ≤40 years, finds KEGG hsa03013 enrichment, then performs CSE1L depletion and mechanistically links CSE1L to a Ran-GTP-dependent role in pre-60S ribosomal subunit export.
• The result: CSE1L depletion reduces growth, proliferation, and clonogenic capacity by targeting leukemia stem cells, revealing nucleocytoplasmic transport and ribosomal subunit export as vulnerabilities in pediatric/AYA AML.

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