Sense-and-respond: Engineered bacteria drive epithelial repair during gut inflammation.

A reactive oxygen species-responsive probiotic Escherichia coli engineered to sense intestinal inflammation delivers IL-22-Fc locally to promote epithelial repair.

• Why it matters: In inflammatory bowel disease, effective mucosal healing requires therapies that can detect inflammation and act locally rather than broadly.
• What they did: Zhao et al. engineered an ROS-responsive Escherichia coli strain that senses intestinal inflammation and responds by locally delivering IL-22-Fc.
• The result: The integrated sense-and-respond platform supports inflammatory bowel disease diagnosis and mucosal healing by coupling inflammation sensing to IL-22-Fc delivery.

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