Gut microbiome and metabolomics reveal the role of thioproline in attenuating colorectal cancer-associated inflammation.

Thioproline treatment in colorectal cancer (CRC) mice significantly reshaped gut microbiota composition and metabolism, restoring CRC-linked microbial metabolites and interactions toward healthy patterns.

• Why it matters: CRC is linked to gut microbiota dysbiosis and intestinal inflammation, but whether thioproline can counter these changes through microbial regulation was unclear.
• What they did: Fecal and intestinal tissue samples from health, CRC, and thioproline-treated CRC mice were analyzed with integrated metagenomics and metabolomics, including microbial-metabolite interaction network assessment and linoleic acid measurement.
• The result: Thioproline returned CRC-associated gut microbiota and bacterial metabolites to near-normal levels, increased linoleic acid, and hematoxylin and eosin staining showed alleviated intestinal inflammation in CRC mice.

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