OSCAR: an omics atlas of paired single-cell ATAC-seq and RNA-seq for decoding cell-specific gene regulation.

OSCAR catalogs 7749,898 paired human cells from 1136 samples across 30 tissue types, enabling single-cell joint clustering and peak-to-gene linkage for regulatory programs.

• Why it matters: Rapid growth of paired scATAC-seq and scRNA-seq datasets creates an urgent need for comprehensive integration to map regulatory landscapes at single-cell resolution.
• What they did: OSCAR curates large-scale paired scATAC-seq and scRNA-seq data and adds regulatory annotations, including super-enhancers, eRNAs, SNPs, eQTLs, TF binding sites, and CRISPR/Cas9 target sites.
• The result: The platform provides online tools for cell type enrichment, sequence-based peak regulatory analysis, and peak-to-gene linkage, supporting queries across human tissues and diseases.