PED in 2027: integrating experimental and predicted protein conformational ensembles at scale.

PED 2027 expands the Protein Ensemble Database by integrating experimental and computational ensemble collections, including AlphaFlex ensembles for 10 022 human proteins with IDRs.

• Why it matters: Structural ensembles for intrinsically disordered proteins and regions are needed for studying conformational behavior, but deposition and comparison across experimental and prediction methods require standardized, scalable infrastructure.
• What they did: PED 2027 (released September 2026) adds a multi-method collection targeting 3319 DisProt proteins and 2452 curated disordered regions, plus AlphaFlex ensembles for 10 022 human proteins, retaining alternative predictions as independent, provenance-tagged records.
• The result: The platform’s deposition workflow, controlled vocabulary, analysis tools, and redesigned interface/API enable interoperable, analysis-ready discovery, visualization, download, and programmatic access to ensemble descriptors.