Omni-ARMD: an integrated genomic and clinical knowledgebase bridging clinical phenotypes and molecular determinants of antimicrobial resistance.

Omni-ARMD integrates clinical AST and genomic resistance evidence to infer organism–antimicrobial genotype–phenotype associations, covering 38 organisms, 52 antimicrobials, and 375 resistance genes.

• Why it matters: AMR molecular determinants are hard to characterize in real-world settings because genomic and clinical data are fragmented, and existing resources separate mechanisms, genotype–phenotype links, and AST results.
• What they did: The knowledgebase uses a confidence-weighted log-odds enrichment framework to quantify genotype–phenotype associations at the organism–antimicrobial level and aggregates cross-domain evidence representations. It includes over 12 million de-identified microbiology records from more than 1 million patients and harmonizes them into over 7.83 million standardized AST records.
• The result: It links over 5.16 million clinical records to genomic evidence, achieving a 65.86% match rate and 2.61% coverage of organism–antimicrobial pairs, enabling integrative AMR discovery.