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Bioresorbable metal-free molecular magnets enable untethered organ monitoring.
Nature materials · · Journal Article
Wu, Yue + more
Abstract ↗AI summary
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A bioresorbable, metal-free molecular magnet from graphitic carbon nitride achieves metallic-level ferromagnetism and enables continuous untethered multi-organ monitoring in porcine models.
- Why it matters: Metal-free molecular magnets could improve biocompatibility and resorbability, but prior materials lacked ferromagnetic strength for high-fidelity sensing at clinically relevant tissue depths.
- What they did: The team engineered graphitic carbon nitride via de-nitrogenation to create spin centers in a reconstructed π-σ conjugated framework, then integrated it into epicardial patches and injectable hydrogels for organ-scale magnetic sensing.
- The result: Using a skin-interfaced Hall array, they continuously assessed ejection fraction for 4 weeks in porcine models, producing clinical-grade trajectories comparable to standard-of-care echocardiography, followed by benign bioresorption.
The findingWhy it mattersWhat they didThe result
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