A brainstem module for backward locomotion reveals direction-selective premotor circuits.

Activation of PBLC glutamatergic neurons induces backward locomotion in mice, highlighting a specific brainstem module for directional control.

• Why it matters: Understanding the neural circuits for navigational transitions is crucial for comprehending how animals control movement direction, yet these circuits remain largely unknown.
• What they did: The study used neural activation and inhibition techniques on PBLC neurons and their projections, demonstrating their role in backward walking and identifying related brainstem regions.
• The result: Findings establish a supraspinal circuit for backward locomotion and suggest neighboring brainstem modules are linked to different locomotor actions, advancing knowledge of movement control.