Charting the silent variation within us.

The SMaHT Network provides the first body-wide map of somatic mosaicism, establishing a baseline of "normal" human somatic variation.

• Why it matters: Understanding somatic variation is crucial for studying its roles in development, aging, and disease, but measuring this variation has been nearly impossible until now.
• What they did: The network developed benchmarked tools and created a comprehensive map of somatic mosaicism across the human body, covering the full extent of cellular variation.
• The result: This baseline enables future research to test how somatic mosaicism influences health and disease, advancing knowledge of human biology and pathology.