Beyond prediction: The evolving role of artificial intelligence in genome editing.

AI now enables the design of de novo genome-editing enzymes, expanding beyond initial predictive applications in genome engineering.

• Why it matters: Understanding and harnessing AI's evolving role is crucial for advancing precise and efficient genome editing technologies, addressing current limitations in molecular design.
• What they did: The authors review the progression from early AI applications in predicting guide RNA activity and off-target effects to recent developments in transformer-based protein language models and generative AI for molecular design.
• The result: This shift allows AI-driven frameworks to evolve genome-editing proteins and create novel molecular architectures, potentially transforming the future of genome engineering.