PWAS Atlas: a comprehensive knowledgebase of proteome-wide association studies.

PWAS Atlas catalogs 40,609 associations among 4,585 genes/proteins and 763 traits from 118 publications and 841 GWAS datasets, serving as a comprehensive resource.

• Why it matters: The rapid growth of PWAS research lacks a centralized, organized platform, limiting efficient access and exploration of proteome-wide association findings crucial for understanding disease mechanisms.
• What they did: The authors developed PWAS Atlas, a web-based knowledgebase that consolidates literature-curated and large-scale PWAS data, featuring interactive knowledge graphs and comparative analysis tools.
• The result: PWAS Atlas enables standardized retrieval, visualization, and comparison of PWAS data, facilitating investigation of protein-trait associations and advancing insights into disease biology.