Cell RepJClub
Viral infection activates the IRF1-BAK axis to drive mitochondria-derived inflammation.
Cell Reports · · Journal Article
Ye, Wang + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
BAK is an interferon-stimulated gene up-regulated by the STAT1–IRF1 axis during virus infection, and its mitochondrial accumulation triggers mitochondria-derived inflammatory pathogenesis.
- Why it matters: A common mechanism for how virus infection promotes mitochondria-derived inflammation via DAMP release is unknown, limiting targeted anti-inflammatory therapeutic development.
- What they did: Viral infection induces STAT1-dependent IRF1 up-regulation, which binds an ISRE site in the BAK promoter to drive BAK up-regulation; RNA and DNA viruses do this, and Bak -/- mice were used.
- The result: BAK-dependent mitochondrial outer-membrane permeabilization and inflammatory responses occur, and in Bak -/- mice both IAV and SFTSV trigger BAK up-regulation and BAK-dependent lethal inflammation.
The findingWhy it mattersWhat they didThe result
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