A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.

A common IRF7 haplotype elevates IFN-α induction, boosting antiviral responses but increasing autoimmune risk in humans and mice.

• Why it matters: Understanding genetic factors that influence immune responses can reveal why some individuals are more prone to autoimmune diseases like lupus, addressing gaps in disease mechanisms and potential therapies.
• What they did: The study analyzed a prevalent IRF7 haplotype through genetic mapping, ancient DNA, and CRISPR-engineered mouse models, examining its effects on IRF7 activity and immune responses.
• The result: The haplotype enhances IRF7 activity, leading to stronger antiviral defenses and higher autoantibody levels, highlighting its dual role in immune protection and autoimmunity.