Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.

Pharmacological strategies targeting multiple cellular pathways show promise in combating sarcopenia, a major cause of frailty in aging populations, with recent clinical trials indicating progress.

• Why it matters: Sarcopenia significantly impacts health and healthcare systems worldwide, yet no approved treatments exist due to its complex causes, underscoring the urgent need for effective therapies.
• What they did: Researchers reviewed mechanisms underlying muscle wasting and explored interventions such as NAD+-related molecules, mTORC1 inhibitors, myostatin inhibitors, and others, supported by emerging clinical trials.
• The result: These multifaceted approaches could enhance muscle strength and function, paving the way for therapies that promote healthy aging by extending both lifespan and healthspan.