PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension.

PUS7-mediated pseudouridylation of TGFBI is linked to pulmonary hypertension progression in lung tissues.

• Why it matters: Understanding epigenetic modifications like RNA pseudouridylation in PH can reveal new mechanisms driving vascular remodeling and identify potential therapeutic targets.
• What they did: Researchers generated a single-base resolution pseudouridine landscape in lung tissues from PH patients and analyzed PUS7 expression through genetic and pharmacological methods, including overexpression and inhibition.
• The result: PUS7 upregulation stabilizes TGFBI via pseudouridylation, activating PI3K-AKT signaling, and disrupting this pathway through inhibition alleviates PH, highlighting PUS7 as a promising treatment target.