Structure-Function Relationship as the Foundation for Cardiac Myosin Inhibition in Hypertrophic Cardiomyopathy.

Understanding myosin structure-function relationships has enabled the development of targeted therapies for hypertrophic cardiomyopathy.

• Why it matters: Hypertrophic cardiomyopathy (HCM) can be obstructive or nonobstructive, and current treatments lack precision; understanding myosin's role could improve patient outcomes.
• What they did: The study reviews how basic science on myosin function and structure informed the creation of precision therapies for HCM, integrating insights from molecular to clinical levels.
• The result: This approach advances personalized treatment strategies for HCM, potentially improving management and prognosis by targeting specific molecular mechanisms.