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Generalised eruptive histiocytosis mimicking lymphoma relapse in a patient with previous diffuse large B-cell lymphoma.
The Lancet · · Case Reports
Martins, Caetano + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
A 92-year-old man with prior diffuse large B-cell lymphoma developed generalized eruptive histiocytosis that mimicked lymphoma relapse, then regressed spontaneously over 3 months.
- Why it matters: Cutaneous histiocytoses can resemble both inflammatory disorders and malignancy recurrence, risking misdiagnosis when cancer history biases interpretation.
- What they did: Clinicians evaluated multiple facial, trunk, and upper-limb papules and nodules with skin biopsies, flow cytometry, and PET-CT, then used clinicopathological correlation to classify group C (cutaneous) histiocytosis.
- The result: Biopsies showed a non-Langerhans cell histiocytic infiltrate (CD45, CD68, CD163 positive; CD1a, CD20, PAX5, S100, Langerin negative), and spontaneous regression plus 15 months of follow-up without recurrence supported generalized eruptive histiocytosis.
The findingWhy it mattersWhat they didThe result
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