Reduced SRSF1 expression correlates with LCK exon skipping and impaired Treg induction in immune thrombocytopenia.

Reduced SRSF1 expression in CD4+ naive T cells from immune thrombocytopenia patients is linked to LCK exon 8 skipping and impaired in vitro Treg induction.

• Why it matters: ITP involves antibody-mediated platelet destruction and defective Treg function, but the splicing mechanisms shaping TCR signaling and FOXP3 induction remain unclear.
• What they did: The study used RNA sequencing plus an LCK minigene, RNA pull-down mass spectrometry, and RNA immunoprecipitation to show SRSF1 directly regulates LCK exon 8 skipping.
• The result: SRSF1 overexpression restored in vitro Treg induction, while blocking SRSF1 binding increased exon 8 skipping and reduced TCR activation; exon 8-skipped murine Lck in CD61-knockout mice lowered Treg proportions and platelet counts.

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