Mechanism of epigallocatechin-3-gallate in alleviating polychlorinated biphenyls-induced immunotoxicity in Scyllaparamamosain.

EGCG significantly reduces PCB-induced immunotoxicity and DNA damage in the mud crab Scylla paramamosain, restoring immune function and tissue integrity.

• Why it matters: Pollutants like PCBs threaten marine life by impairing immune responses and causing tissue damage, but effective protective strategies are lacking.
• What they did: Researchers exposed mud crabs to 1 ng/L PCBs for 7 days, then injected EGCG at 1 mg/kg, measuring immune parameters, enzyme activities, gene expression, and tissue health.
• The result: EGCG mitigated apoptosis, increased hemocyte counts, boosted antioxidant enzyme activities, and repaired immune gene expression, highlighting its potential to counteract environmental immunotoxicants.