The bioproduction of prodigiosin: A comprehensive review on the microbial biosynthesis, regulatory mechanism and cost-effective fermentation strategies.

Advances in microbial biosynthesis and fermentation strategies have significantly improved prodigiosin production, with yields reaching new heights and cost reductions.

• Why it matters: Prodigiosin’s diverse biological activities make it a valuable compound for medical, food, and environmental applications, but efficient production methods are needed to meet demand.
• What they did: The review covers recent progress in understanding PG biosynthetic pathways, regulatory mechanisms, and the discovery of new producers, along with fermentation optimization techniques.
• The result: These developments enable the rational design of cost-effective bioprocesses for PG and its derivatives, facilitating their broader application in various industries.