Engineering quorum sensing: new directions for antimicrobial therapy.

Synthetic biology enables targeted disruption and engineering of quorum sensing to combat bacterial virulence and antimicrobial resistance.

• Why it matters: Bacterial quorum sensing is crucial for pathogenicity, and targeting it offers a promising alternative to traditional antibiotics, addressing rising resistance issues.
• What they did: The review discusses how QS and its interference can be harnessed through synthetic biology to develop therapeutic microorganisms and innovative antimicrobial strategies.
• The result: Harnessing QS circuits advances the creation of engineered microbes that detect and eliminate pathogens, paving the way for novel, effective treatments against resistant infections.