Re-balancing immunity with CRISPR-Cas9: Novel strategies for cancer and autoimmune disorders.

CRISPR-Cas9 strategies enable precise reprogramming of immune responses to treat cancer and autoimmune diseases.

• Why it matters: Dysregulated immunity underpins many diseases, with current immunotherapies limited by safety and efficacy issues, highlighting the need for more precise interventions.
• What they did: The review details six CRISPR-Cas9 approaches—knockout, knock-in, activation, interference, base editing, and prime editing—applied to engineer immune cells and restore immune balance.
• The result: These strategies improve anti-tumor immunity and autoimmunity control, paving the way for advanced, safer cellular therapies with enhanced therapeutic potential.