GutJClub
Gut microbiome signatures in colorectal neoplasia: a cross-sectional study across neoplasia stages and subtypes.
Gut · · Multicenter Study · Open access
Louca, Manning + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Gut microbiome signatures show only weak and inconsistent associations with colorectal neoplasia stages and subtypes, with no robust microbial markers identified.
- Why it matters: Understanding microbial signatures in early colorectal lesions could improve early detection and prevention strategies for CRC, but current knowledge is limited and inconsistent.
- What they did: Analyzed stool metagenomes from 1762 participants undergoing colonoscopy, using statistical models and machine learning to identify taxonomic and functional microbial associations with neoplasia.
- The result: Findings indicate minimal microbiome differences between individuals with and without neoplasia, and modest improvements in risk classification, suggesting microbiome shifts may occur later in disease progression.
The findingWhy it mattersWhat they didThe result
- Open access