Proteomic profiling of postmortem prefrontal cortex identifies molecular signatures of borderline personality disorder

Label-free proteomics of postmortem prefrontal cortex from 79 individuals finds BPD-linked dysregulation across mitochondrial, immunological, and neuroplasticity pathways.

• Why it matters: Neurobiological mechanisms in borderline personality disorder remain poorly defined despite imaging and genetic risk findings, motivating molecular profiling of relevant brain tissue.
• What they did: The study compared 36 BPD cases versus 43 controls using label-free brain proteomics, then applied differential expression, co-expression network, and druggability analyses.
• The result: A BPD-associated co-expression module enriched for protein secretory and synaptic processes appears druggable with selective serotonin reuptake inhibitors, and VEGF signaling is implicated as a potential target.

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