Relative expression of THY1 and PDGFRA in equine endometrosis in relation to severity, histopathological features and endometrial transcripts

THY1 relative mRNA expression in equine endometrosis is transiently upregulated in KD category IIA and is elevated with glandular basal lamina disruption, unlike PDGFRA.

• Why it matters: Understanding how stromal integrators and growth factor receptors participate in equine endometrosis helps link tissue remodeling and subfertility to specific transcript changes.
• What they did: Endometrial samples from mares (n = 47) were analyzed by RT-qPCR for THY1 and PDGFRA across Kenney and Doig categories and histopathological features, with transcriptomic correlation to ACTA2, MKI67, ESR1, and PGR.
• The result: THY1 differed across KD categories (p = 0.014) with category IIA vs category I (p = 0.009) and IIB (p = 0.002), and increased with basal lamina disruption (p = 0.022); PDGFRA stayed stable (p > 0.05) while THY1 correlated with ACTA2 (rho = 0.875, p < 0.001) and ESR1 (rho = 0.652, p < 0.001), and PDGFRA correlated with ESR1 (rho = 0.864, p < 0.001) and MKI67 (rho = 0.674, p < 0.001).

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