Citrate-Based Hydrogels Promote Closure of Infected Diabetic Wounds

In diabetic mice with S. aureus–infected wounds, four citrate-based PPCN hydrogel formulations significantly improved cumulative closure versus saline (adjusted p = 0.002–0.021).

• Why it matters: Diabetic foot ulcers can become chronic and infected, raising amputation risk, yet therapies that promote closure with or without infection are still needed.
• What they did: The study tested four PPCN formulations (with A5G81 and/or CMOF Cu2+–releasing nanoparticles) in infected and non-infected diabetic mouse wounds, and assessed closure, in vitro bacterial killing, and in vitro endothelial mesh and in vivo tissue and vascular markers.
• The result: In vitro, CMOF-containing formulations showed the highest killing (90% for A5G81-PPCN-CMOF; 84% for PPCN-CMOF), while A5G81-PPCN and PPCN reduced colonies by 76% and 59%, and PPCN-based hydrogels increased granulation thickness and vascular marker expression in vivo.

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