OPEN: A Community-Informed Metadata Framework for Interoperable Computable Phenotypes

OPEN established a community-informed computable phenotype (CP) metadata framework with 23 candidate fields, enabling interoperable exchange across five libraries.

• Why it matters: CPs need FAIR reporting and sharing, but library metadata and user requirements are not consistently aligned, limiting interoperability and reuse.
• What they did: OPEN combined a cross-library field comparison and literature review with UK stakeholder interviews, a survey, and a workshop to build candidate fields and conformance tiers. It then tested diabetes-related phenotype interoperability via manual and API-mediated mapping, measuring metadata field completeness at 63–76%.
• The result: Thirteen fields aligned across all five libraries, and 22 matched published CP library desiderata; a survey of 124 respondents supported six mandatory elements. The framework provides a credible foundation for a FAIR CP metadata standard, with logic representation and validation viewed as context-dependent.

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