PlanetDiet: Sustainable diets and cardiometabolic health, study protocol for a six-month parallel-group randomized controlled trial in middle-aged adults at cardiovascular risk

PlanetDiet will test whether a Planetary Health Diet improves a composite cardiometabolic health score over six months in 180 Danish adults aged 45–70 at high cardiovascular risk.

• Why it matters: Cardiovascular disease remains a leading cause of death, and diet is a key prevention target, but randomized evidence using a PHD index and novel biomarkers is lacking.
• What they did: In a three-arm, six-month parallel-group RCT, 180 Danish adults are randomized to a PHD, an ovo-lacto-vegetarian diet, or habitual diet, with urine, blood, and faecal sampling plus continuous glucose monitoring and metabolomic/proteomic profiling.
• The result: The trial will quantify diet-linked changes in traditional and novel cardiometabolic risk factors and molecular profiles, informing personalized sustainable dietary interventions and pathway hypotheses.

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