MmuPV1 and HPV E6 Elevate Nuclear Accumulation of IKK? to Impair NF-κB Signaling to Promote Persistent Infection

MmuPV1 E6 increases nuclear localization of IKKβ in mouse keratinocytes, and the E6R130A mutation abolishes this, linking IKKβ relocalization to NF-κB disruption.

• Why it matters: Persistent papillomavirus infection depends on evading NF-κB signaling, but the specific viral mechanism altering IKK complex behavior and localization was unclear.
• What they did: The study tested MmuPV1 E6 and the R130A mutant for binding to IκB kinase (IKK) complex proteins and for effects on NF-κB signaling in mouse keratinocytes, then measured nuclear IKKβ localization.
• The result: MmuPV1 E6 and HPV16 E6 both impair NF-κB signaling and increase nuclear IKKβ localization in keratinocytes, and MmuPV1 E6 RNA-seq data show transcriptional changes linked to increased nuclear IKKβ.

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