PROST: An Open Toolbox, Harmonised Multi-Lab Dataset, and Meta-Analysis of Ankle-Foot Roll-Over Shape

In a harmonised multi-lab dataset of 249 participants, ankle-foot roll-over shape (ROS) is well fit by circular arcs with mean RMS residual 1.9 mm and radius median 410.3 mm.

• Why it matters: Prior ROS work used small, protocol-diverse samples, leaving inter-individual variability and links to body measures unclear for prosthetic and orthotic design.
• What they did: PROST was used to standardise ROS computation and harmonise marker, ground reaction force, and CoP data from four public gait datasets, then circular arcs were fitted per leg and analysed with mixed-effects meta-analysis.
• The result: Between-participant differences explained 42% of log-radius variance (ICC; 95% CI 25–57%) and 47% of circle-centre horizontal-coordinate variance (95% CI 24–65%), while anthropometrics explained negligible variance and faster self-selected walking predicted larger radius and a more posterior centre.

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