Redox regulation of 2-carboxy-D-arabinitol 1-phosphate phosphatase in Fabaceae is associated with high Rubisco dark inhibition

A conserved cysteine-pair motif in Vigna unguiculata CA1Pase is linked to redox regulation and potential homodimer formation, shaping dark inhibitor accumulation.

• Why it matters: Rubisco output depends on limiting inhibitor buildup, but CA1Pase regulation—especially the role of its C domain—remains unclear.
• What they did: The study combined in silico and in vitro analyses of Vigna unguiculata CA1Pase to map structural regions and motifs, then compared cysteine-residue variations across species with inhibitor accumulation.
• The result: Changes in one or both cysteines in the motif are associated with lower dark inhibitor accumulation levels versus related species, and the C domain is identified as regulatory with evolutionary origins explored.

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