Late-Stage Concentration of Cardiovascular-Kidney-Metabolic Syndrome Burden in US Adults: Disability-Adjusted Life Years Across AHA Stages, 2005 to 2023

In US adults (NHANES 2005–2023), CKM syndrome accounts for 20.0 million DALYs annually, with stages 3–4 generating 76% of attributable YLL.

• Why it matters: DALYs inherently reward later-stage outcomes, so it is unclear how much this could bias cardiovascular prevention priorities for CKM syndrome and where the population is accumulating.
• What they did: The study pooled nine NHANES cycles (2005–2023), assigned CKM stages 0–4 using measured cardiometabolic and kidney markers plus 10-year PREVENT risk, and computed YLD and YLL using GBD disability weights and linked mortality (1999–2018).
• The result: In 2021–2023, 15.8% of adults were in stages 3–4, while stage 1 rose 3.1% per year (2006–2016) and stage 1 mortality matched stage 0 (HR 0.99, 95% CI 0.78–1.25).

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