Exercise reshapes cellular immunity toward anti-inflammation and diminishes CCR4 levels on LFA-1αhighCD4+ T cells in multiple sclerosis

In persons with multiple sclerosis, three months of high-intensity interval training reduces CCR4 on LFA-1αhighCD4+ T cells, linked to disease biomarkers, with effects persisting at follow-up.

• Why it matters: Regular exercise is recommended for MS, but human evidence for specific immune remodeling and its cellular targets has been limited.
• What they did: In a randomized controlled trial, pwMS completed three months of high-intensity interval training or passive control, with assessments at baseline, post-intervention, and four-week follow-up, plus healthy matched controls.
• The result: Exercise improved the Treg-to-TH17.1 ratio, lowered systemic inflammation, and decreased inflammatory-protein signals in PBMCs (>7000 proteins), while CCR4 expression on the LFA-1αhighCD4+ T-cell subset was reduced after training.

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