bioRxivJClub
Dated public evidence and known genes for retrospective evaluation of gene prioritization
bioRxiv · · Preprint · Open access
Huang, Wang
Abstract ↗AI summary
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Per-gene evidence tables for oncology, inflammatory bowel disease, metabolism, and psoriasis add a time axis across 183 archived releases and a leakage axis (A–E) to support retrospective gene prioritization.
- Why it matters: Retrospective evaluation needs public evidence that predates when evaluated genes became known, but current releases mix older and newer findings.
- What they did: The data descriptor compiles per-gene evidence from 20 public sources, assigning each feature a release date within 183 archived releases and provenance class A–E with two risk grades defining five feature sets.
- The result: Nineteen dated known-gene lists are anchored to the first trial, study, release, or classification supporting each gene, enabling leakage-aware, time-resolved retrospective assessments.
The findingWhy it mattersWhat they didThe result
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