Hypoxemia is an Independent Risk Factor for Perioperative Thrombosis at High Altitude: A Retrospective Study of 11,084 Patients

Hypoxemia is an independent risk factor for perioperative thrombosis in 11,084 surgical patients at high altitude, with the strongest single-factor diagnostic performance (AUC 0.732).

• Why it matters: Perioperative thrombosis occurs more often at high altitudes, creating safety risks for surgical patients and a need for early screening targets beyond traditional factors.
• What they did: The authors retrospectively analyzed 11,084 surgical patients, comparing thrombosis (n=1,631; 14.7%) versus non-thrombosis groups and using multivariate logistic regression with 21 candidate risk factors including PaO2.
• The result: The multivariate model identified hypoxemia as independently associated with thrombosis (P < 0.05), enabling risk prediction with AUC 0.862 and supporting correction of perioperative hypoxic states.

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